Clare is a city in Clare and Isabella counties in the U.S. state of Michigan. Located primarily in Clare County, the population was 3,118 at the 2010 census. North-south U.S. Highway�127 forms the eastern boundary for much of the city and has a junction with east-west US�10 on the east side of the city. US�10 connects with Midland, 33 miles to the southeast, and with US�131 at Reed City, 44 miles to the west. US�127 connects with Mount Pleasant, 13 miles to the south, and with Harrison, 14 miles to the north. The southern terminus of M-115 is in downtown Clare.